Molecular mechanisms involved in the adaptation to amino acid limitation in mammals

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• 作者：Cé ; dric Chaveroux ; Sarah Lambert-Langlais ; Yoan Cherasse ; Julien Averous ; Laurent Parry ; Valé ; rie Carraro ; Cé ; line Jousse ; Anne-Catherine Maurin ; Alain Bruhat ; Pierre Fafournoux
• 关键词：Amino acid ; Gene expression ; GCN2 ; ATF4 ; ATF2
• 刊名：Biochimie
• 出版年：2010
• 出版时间：July 2010
• 年：2010
• 卷：92
• 期：7
• 页码：736-745
• 全文大小：575 K

文摘

In mammals, metabolic adaptations are required to cope with episodes of protein deprivation and malnutrition. Consequently, mammals have to adjust physiological functions involved in the adaptation to amino acid availability. Part of this regulation involves the modulation of the expression of numerous genes. In particular, it has been shown that amino acids by themselves can modify the expression of target genes. This review describes the regulation of amino acids homeostasis and the their role as signal molecules. The recent advances in the understanding of the molecular mechanisms involved in the control of mammalian gene expression in response to amino acid limitation will be described.