Efavirenz pharmacogenetics in a cohort of Italian patients
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- 作者：Jessica Cusatoa ; 1 ; jessica.cusato@yahoo.it" class="auth_mail" title="E-mail the corresponding author ; Cristina Tomaselloa ; b ; Marco Simielea ; c ; Andrea Calcagnoa ; Stefano Bonoraa ; Letizia Marinaroa ; Anna Leggierib ; Sarah Allegraa ; Giovanni Di Perria ; Antonio D&rsquo ; Avolioa
- 关键词：Pharmacokinetics ; SNP ; ABCB1 ; CYP2B6 ; HNF4α
- 刊名：International Journal of Antimicrobial Agents
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：47
- 期：2
- 页码：117-123
- 全文大小：772 K
文摘
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Efavirenz (EFV) concentrations are associated with CYP2B6, ABCB1 and HNF4α SNPs.
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CYP2B6 516 TT and ABCB1 3435 TT genotypes predict EFV concentrations >4000 ng/mL.
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Genetic patterns using different SNPs may be useful in optimising EFV dosing.