Engineered nanoparticles of Efavirenz using methacrylate co-polymer (Eudragit-E100) and its biological effects in-vivo
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- 作者：B.N. Vedha Haria ; vedhahari@scbt.sastra.edu" class="auth_mail" title="E-mail the corresponding author ; N. Narayananb ; K. Dhevendarana ; D. Ramyadevia
- 关键词：HIV ; Human immunodeficiency virus ; HAART ; Highly active anti-retroviral therapy ; AIDS ; Acquired immunodeficiency virus syndrome ; 3Tc ; Lamivudine ; FTC ; Emtricitabine ; BCS ; Biopharmaceutical Classification System ; CNS ; Central nervous system ; BBB ; Blood Brain Barrier ; ART ; Antiretroviral therapy ; NRTIs ; Nucleoside Reverse Transcriptase Inhibitors ; PIs ; Protease inhibitors ; RDS ; Rate-determining step ; RES ; Reticuloendothelial Systems ; FDA ; Food and drug administration ; FBS ; Fetal bovine serum ; CAF
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：67
- 期：Complete
- 页码：522-532
- 全文大小：1909 K
文摘
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Efavirenz loaded polymeric nanoparticle developed with small size and high drug loading
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Cytotoxicity Nanoparticle was evaluated using Human Lymphatic cell line (C8166).
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Nanoparticle enhanced the dissolution in-vitro.
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Nanoparticle accumulated more in testes and brain after Intraperitoneal administration.