Transition modeling of neuropsychiatric impairment in HIV
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- 作者：Kuteesa R. Bisasoa ; b ; kuteesar@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Jackson K. Mukonzoa ; c ; Ene I. Etted
- 关键词：Neuropsychiatric impairment ; Efavirenz ; Continuous time Markov model ; NONMEM ; Monte Carlo simulation ; Duration of NPI
- 刊名：Computers in Biology and Medicine
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：73
- 期：Complete
- 页码：141-146
- 全文大小：558 K
文摘
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A continuous time Markov model adequately described efavirenz treatment-associated neuropsychiatric impairment.
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Efavirenz dose reduction from 600 to 400 mg would reduce the duration of neuropsychiatric impairment in HIV patients who get impaired without affecting efficacy.
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Delayed neuropsychiatric symptoms are less likely related to efavirenz exposure.