Elucidation of the binding mechanism of renin using a wide array of computational techniques and biological assays
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文摘

The structure of renin remains practically stable upon drug binding.

An extensive hydrogen bond network is developed between renin and compounds.

Compound binding is driven by van der Waals and nonpolar contributions.

The (H2O/Na+) environment has a rather minor effect on the drug–renin interaction.

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