A rapid lateral flow stool antigen immunoassay and ¹⁴C-urea breath test for the diagnosis and eradication of Helicobacter pylori

详细信息    查看全文

• 作者：Zarife Kuloğ ; lu ; Aydan Kansu ; Ceyda Tuna Kı ; rsaç ; lı ; oğ ; lu ; Gonca Ü ; stü ; ndağ ; Derya Aysev ; Arzu Ensari ; Nuriye Ö ; zlem Kü ; ç ; ü ; k ; Nurten Girgin
• 关键词：Children ; Helicobacter pylori ; Immunoassay ; Immunochromatography ; Stool antigen test ; ¹⁴C urea breath test
• 刊名：Diagnostic Microbiology and Infectious Disease
• 出版年：2008
• 出版时间：December 2008
• 年：2008
• 卷：62
• 期：4
• 页码：351-356
• 全文大小：152 K

文摘

Our aim was to evaluate diagnostic accuracy of rapid immunochromatographic stool antigen test (Rapid HpSA; LİNEAR Chemical, Barcelona, Spain) and a practical low-dose ¹⁴C urea breath test (UBT) (Heliprobe™) test before and after eradication therapy. One hundred nine children with abdominal symptoms (age range, 5–17 years; mean, 12.1) underwent endoscopy, ¹⁴C-UBT, and Rapid HpSA. Patients were defined as Hp infected when histology was positive for Hp. Forty children (36.6 % ) were Hp infected. The sensitivity of Rapid HpSA and ¹⁴C-UBT was 65 % and 92.5 % (P = 0.0003), respectively; the specificity of Rapid HpSA and ¹⁴C-UBT was 92.3 % and 85.5 % (P = 0.180), respectively. After eradication therapy endoscopy, ¹⁴C-UBT and Rapid HpSA were repeated. The eradication rate was 70.5 % . After eradication, the sensitivity of Rapid HpSA and ¹⁴C-UBT was 60 % and 100 % , respectively; the specificity of Rapid HpSA and ¹⁴C-UBT was 100 % . ¹⁴C-UBT was more reliable than the Rapid HpSA test for the diagnosis and for confirming eradication of Hp infection.