Excellent outcome following transplantation of a domino donor liver with high-grade macrosteatosis

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• 作者：Gissou Azabdaftari ; Elizabeth A. Pomfret ; Mary Ann Simpson ; James J. Pomposelli ; W. David Lewis ; Roger L. Jenkins ; Fredric D. Gordon ; Urmila Khettry
• 关键词：Hepatic ; Allograft ; Fatty
• 刊名：Pathology - Research and Practice
• 出版年：2004
• 出版时间：August 2004
• 年：2004
• 卷：200
• 期：7-8
• 页码：581-587
• 全文大小：414 K

文摘

Severe macrosteatosis in the donor liver is considered a major predictive factor of primary graft non-function. Such livers are usually discarded despite an ever-growing need for donor livers. We report our recent experience in a patient (#1) who had an excellent outcome following liver transplantation (LT) of a 65–70 % macrosteatotic graft and compare his findings with those of two other (#2 and #3) recipients of moderate to severe macrosteatotic grafts. Both patients (#2 and #3) had initial diminished function, with recovery in patient #2 but delayed graft non-function requiring re-LT (day 24) in patient #3. Patient #1 had no intra-operative complications, while patient #2 had mild complications due to prior adhesions and graft capsular laceration. In patient #3, extensive intra-abdominal adhesions resulting in excessive bleeding occurred during recipient hepatectomy. Total ischemic times: 2.48, 6.10, and 8.18 h; total blood product usage: 43, 81, and 223 units; post-LT hospital stay: 9, 21, and 69 days were seen in patients #1, #2 and #3, respectively. In conclusion, post-LT excellent graft function was seen in one recipient of 65–70 % macrosteatotic graft. Transplantation of grafts with moderate/severe macrosteatosis may be inadvisable in patients with extensive intra-abdominal adhesions with expectant excessive bleeding and long ischemia times.