Design, synthesis and biological evaluation of 1H-pyrrolo[2,3-b]pyridine and 1H-pyrazolo[3,4-b]pyridine derivatives as c-Met inhibitors
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- 作者：Na Liua ; 1 ; Yanfen Wanga ; 1 ; Gongchao Huangb ; 1 ; Conghui Jib ; Wei Fana ; Haitao Lib ; Ying Chengb ; Hongqi Tianc ; tianhongqi@irm-cams.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：c-Met inhibitor ; Azaindole ; Azaindazole ; Synthesis ; Biological evaluation
- 刊名：Bioorganic Chemistry
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：146-158
- 全文大小：1655 K
文摘
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Novel 7-azaindole and 7-azaindazole derivatives were designed and synthesized.
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Compound 9 displayed strong c-Met kinase, MKN-45 cell and EBC-1 cell inhibition.
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The synthesis methods of 7-azaindole and 7-azaindazole derivatives were developed.