Red blood cell Pig-a assay and PIGRET assay in rats with azathioprine
详细信息 查看全文
- 作者：Ikuma Yoshida ; Akemi Matsumoto ; Yumi Sakai ; Yumiko Harada ; Tsuneo Hashizume ; PhD degree ; tsuneo.hashizume@takeda.com
- 关键词：%RET ; percent of reticulocytes ; 6-MP ; 6-mercaptopurine ; APC ; allophycocyanin ; Aza ; azathioprine ; ENU ; ethylnitrosourea ; FITC ; fluorescein isothiocyanate ; GPI ; glycosylphosphatidylinositol ; HPRT ; hypoxanthine-guanine phosphoribosyltransferase ; IARC ; international agency for research on cancer ; JEMS ; Japanese environmental mutagen society ; MF ; mutant frequency ; MMS ; mammalian mutagenicity study ; PBS ; phosphate-buffered saline ; PE ; phycoerythrin ; Pig-a gene ; phosphatidylinositol glycan anchor biosy
- 刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：811
- 期：Complete
- 页码：60-64
- 全文大小：606 K
- 卷排序：811
文摘
As a part of a collaborative study, Pig-a assay of azathioprine was investigated. Positive control, ENU showed significant result in both RBC Pig-a and PIGRET assays. Azathioprine did not increase Pig-a mutant frequency in both assays. The mutagenicity of azathioprine was negligible in rats with single dose.