KAl(SO₄)₂·12H₂O supported on silica gel as a novel heterogeneous system catalyzed biginelli reaction: One-pot synthesis of di-hydropyrimidinones under solvent-fr

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• 作者：Javad Azizian ; Ali A. Mohammadi ; Ali R. Karimi and Mohammad R. Mohammadizadeh
• 刊名：Applied Catalysis A: General
• 出版年：2006
• 出版时间：20 January 2006
• 年：2006
• 卷：300
• 期：1
• 页码：85-88
• 全文大小：112 K

文摘

3,4-Dihydropyrimidin-2(1H)-ones derivatives were synthesized in moderate to high yields in one-pot three component reaction from the corresponding aldehydes, ketones or 1,3-dicarbonyl compounds and urea, in the presence of catalytic amount of KAl(SO₄)₂·12H₂O (Alum) supported on silica gel (Alum-SiO₂) as a non-toxic, reusable, inexpensive and easily available reagent, under solvent-free conditions at 80 °C. Compared to the classical Biginelli reaction, this new method consistently has the advantage of good yields.