A convenient transformation of N-substituted ureas into N-(t-butoxycarbonyl)amines using a copper(II) salt-lithium t-butoxide system

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• 作者：Yamaguchi ; Jun-ichi ; Shusa ; Yuji ; Suyama ; Takayuki
• 关键词：azo ; azo compounds ; carbamates ; copper ; copper compounds ; ureas
• 刊名：Tetrahedron Letters
• 出版年：1999
• 出版时间：November 19, 1999
• 年：1999
• 卷：40
• 期：47
• 页码：8251-8254
• 全文大小：190 K

文摘

Treatment of N-substituted ureas with a copper(II) reagent prepared from lithium t-butoxide and copper(II) halide led to give the corresponding N-(t-butoxycarbonyl)amines under mild conditions. On the contrary, no reaction of N,N-disubstituted ureas proceeded. Under the conditions the generation of azodicarbonyldiamide derivatives is expected. Further treatment of azodicarbonyldiamide derivatives with the copper(II) reagent also proceeded to give the corresponding N-(t-butoxycarbonyl)amines.