Bifunctional AgOAc/ThioClickFerrophos catalyzed asymmetric 1,3-dipolar cycloaddition reaction of azomethine ylides to nitroalkenes

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• 作者：Midori Kimura ; Yukiko Matsuda ; Akihiro Koizumi ; Chihiro Tokumitsu ; Yuichiro Tokoro ; Shin-ichi Fukuzawa ; ^{orgsynth@kc.chuo-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Silver acetate ; P ; S-Ligand ; Nitroalkene ; Cycloaddition ; Azomethine ylide
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：26 May 2016
• 年：2016
• 卷：72
• 期：21
• 页码：2666-2670
• 全文大小：375 K

文摘

AgOAc/ThioClickFerrophos (TCF) complex catalyzed the 1,3-dipolar cycloaddition of azomethine ylides (glycine imino ester) to nitroalkenes. The corresponding endo-cycloadducts (88:12–98:2 endo/exo) were afforded in good yields with high enantioselectivities, up to 98% ee, without addition of external amine. AgOAc/TCF works as a bifunctional (Lewis acid and base) catalyst.