Fronto-temporal connectivity in never-medicated patients with first-episode schizophrenia: A DTI study

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• 作者：Shaimaa Abdelsattar Mohammad^a ; ^{shaimaa96@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Hossam Moussa Sakr^a ; ^{drhossamsakr@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Sameh Mohamed Yousri Bondok^b ; ^{Drsamehbondok@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Dalia Abdel Moneim Mahmoud^b ; ^{dollycage@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Hanan M.E. Azzam^b ; ^{hananazzam98@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Safeya Effat^b ; ^{Effatsafeya@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：First episode schizophrenia ; DTI ; Axial and Radial diffusivity ; Superior longitudinal fasciculus ; External capsule
• 刊名：The Egyptian Journal of Radiology and Nuclear Medicine
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：47
• 期：1
• 页码：255-262
• 全文大小：1551 K

文摘

To assess fronto-temporal connectivity in never-medicated patients with first episode schizophrenia (FES).

Material and methods

Twelve never-medicated patients (median age = 25.5 y) with first episode schizophrenia (according to DSM-IV system) and sixteen demographically matched controls were enrolled in the study. Conventional MRI sequences were obtained. Single shot echo-planar DTI was acquired in 32 non-collinear directions. Tractography of the direct pathway of the superior longitudinal fasciculus (SLFd) and uncinate fasciculus of both hemispheres was performed, and ROIs at the anterior cingulum and external capsule of both hemispheres were drawn. Fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD) and Trace of the ROIs and reconstructed tracts were calculated. Group comparison was performed using independent sample t-test and Fisher’s exact test.

Results

Compared to healthy participants, there was significant reduction of FA of the left external capsule (p = 0.001) with increase in RD and Trace (p = .004, .048 respectively). However, the right SLFd showed significant reduction of AD (p = 0.005) and the left SLFd showed significant reduction of its volume (p = 0.02).

Conclusion

In patients with FES, impaired white matter connectivity was recognized in the right SLFd and left external capsule associated with reduction in the volume of the left SLFd.