Effects of the benzodiazepine GABAA α1-preferring antagonist 3-isopropoxy-β-carboline hydrochloride (3-ISOPBC) on alcohol seeking and self-administration in baboons
Acute doses of 3-ISOPBC did not decrease alcohol seeking or consumption in baboons. Chronic doses of 3-ISOPBC reduced alcohol consumption. Chronic doses of 3-ISOPBC did not affect consumption of a non-alcoholic beverage. Effects of chronic doses of 3-ISOPBC on consumption were specific to alcohol.