Polymeric microdevices for transdermal and subcutaneous drug delivery

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• 作者：Manuel Ochoa ; Charilaos Mousoulis ; Babak Ziaie ; ^{bziaie@purdue.edu}
• 关键词：Polymeric microdevices ; BioMEMS ; Microfluidics ; Transdermal drug delivery ; Micropumps
• 刊名：Advanced Drug Delivery Reviews
• 出版年：2012
• 出版时间：November, 2012
• 年：2012
• 卷：64
• 期：14
• 页码：1603-1616
• 全文大小：2732 K

文摘

Low cost manufacturing of polymeric microdevices for transdermal and subcutaneous drug delivery is slated to have a major impact on next generation devices for administration of biopharmaceuticals and other emerging new formulations. These devices range in complexity from simple microneedle arrays to more complicated systems incorporating micropumps, micro-reservoirs, on-board sensors, and electronic intelligence. In this paper, we review devices currently in the market and those in the earlier stages of research and development. We also present two examples of the research in our laboratory towards using phase change liquids in polymeric structures to create disposable micropumps and the development of an elastomeric reservoir for MEMS-based transdermal drug delivery systems.