Immune responses elicited by the GEN-003 candidate HSV-2 therapeutic vaccine in a randomized controlled dose-ranging phase 1/2a trial
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- 作者：Jessica Baker Flechtner<sup> ; sup><sup>jessica.flechtner@genocea.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Deborah Long ; Shane Larson ; Veronica Clemens ; Amy Baccari ; Lena Kien ; Jason Chan ; Mojca Skoberne ; Matthew Brudner ; Seth Hetherington
- 关键词：Herpes simplex virus ; Vaccine ; Immunotherapy ; Immune response
- 刊名：Vaccine
- 出版年：2016
- 出版时间：17 October 2016
- 年：2016
- 卷：34
- 期：44
- 页码：5314-5320
- 全文大小：474 K
文摘
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Cellular and humoral responses were boosted in GEN-003 vaccinated HSV-2 seropositive subjects.
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Matrix-M2 adjuvant potentiated the immune responses to ICP4 and gD2 antigens contained in GEN-003.
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No immune correlates of anti-viral activity have yet been identified.