Pneumococcal pneumonia in adults 60 years or older: Incidence, mortality and prevention

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• 作者：Angel Vila-Corcoles^a ; Xabier Ansa^a ; Olga Ochoa-Gondar^a ; ^{oochoa.tarte.ics@gencat.cat" class="auth_mail" title="E-mail the corresponding author} ; Eva Satue^a ; Cinta de Diego^a ; Teresa Rodriguez-Blanco^b ; on behalf of EPIVAC Research Team
• 关键词：Epidemiology ; Incidence ; Mortality ; Pneumococcal pneumonia ; Streptococcus pneumoniae
• 刊名：Medicina Clínica
• 出版年：2016
• 出版时间：4 March 2016
• 年：2016
• 卷：146
• 期：5
• 页码：199-202
• 全文大小：211 K

文摘

This study investigated the burden (incidence, mortality and serotype distribution) of pneumococcal pneumonia among older adults in the region of Tarragona (Spain).

Methods

Population-based cohort study involving 27,204 individuals ≥60 years in Tarragonès county (Southern Catalonia), who were prospectively followed between 01/12/2008 and 30/11/2011. Bacteremic and nonbacteremic (positive sputum culture and/or urinary antigen test) pneumococcal pneumonias were recruited.

Results

A total of 125 pneumococcal pneumonias (16 bacteremic and 109 nonbacteremic) was observed. Incidence rates (per 1000 person-years) were 0.21 (95% confidence interval [CI]: 0.13–0.35) for bacteremic cases and 1.45 (95% CI: 1.20–1.75) for nonbacteremic cases. Case-fatality rate was 10.4% (12.5% in bacteremic and 10.1% in nonbacteremic cases). Five serotypes (types 3, 6C, 19A, 22F and 35B) were the most common serotypes, accounting for 64.3% of overall isolated serotypes. 73.1% of cases were due to the strains included in the 23-valent vaccine whereas 53.6% were due to the strains included in the 13-valent vaccine.

Conclusion

The burden of pneumococcal pneumonia remains considerable (especially among oldest people and nursing-home residents) despite a publicly funded anti-pneumococcal vaccination program operative for several years.