Molecular mechanisms of apoptosis and cell selectivity of zinc dithiocarbamates functionalized with hydroxyethyl substituents
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- 作者：Yee Seng Tana ; Kah Kooi Ooib ; Kok Pian Angb ; Abdah Md Akimb ; Yoke-Kqueen Cheahb ; ykcheah@medic.upm.edu.my" class="auth_mail" title="E-mail the corresponding author ; Siti Nadiah Abdul Halima ; Hoi-Ling Senga ; c ; Edward R.T. Tiekinka ; Edward.Tiekink@um.edu.my" class="auth_mail" title="E-mail the corresponding author ; Edward.Tiekink@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Annexin V&ndash ; FITC ; Recombinant annexin V conjugated to fluorescein isothiocyanate ; AO ; Acridine orange ; APAF-1 ; Apoptosis activating factor-1 ; ATM ; Ataxia telangiectasia mutated gene ; ATR ; Attainable total reflectance ; BAX ; BCL-2 associated X protein ; BCL-2 ; B-cell CLL/lymphoma 2 ; BID ; BH3 interacting domain death agonist ; BNIP3L ; BCL2/adenovirus E1B 19 ; kDa interacting protein 3-like ; BIRC5 ; Baculoviral IAP repeat containing 5 ; c-Abl ; c-Abl oncogene 1 ; non-receptor tyrosine kinase ; Carbo
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：150
- 期：Complete
- 页码：48-62
- 全文大小：3130 K
文摘
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[Zn(S2CNRR′)2]2 (1–4) are more cytotoxic to human cancer cells than normal cells.
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2 (R = R′ = CH2CH2OH) is selectively cytotoxic against A2780.
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1–4 cause apoptosis in HT-29 cells by both intrinsic and extrinsic pathways.
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1–4 inhibit cell invasion by down-regulation of NF-ĸB.
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All but 3 are topoisomerase I inhibitors.