Inhibitor of apoptosis proteins (IAPs) as regulatory factors of hepatic apoptosis

详细信息    查看全文

• 作者：Kewei Wang ; Bingliang Lin
• 关键词：IAPs ; inhibitor of apoptosis proteins ; BIR ; Baculovirus IAP repeat ; FLIPs ; FLICE-inhibitory proteins ; Smac/Diablo ; Second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI ; TNF ; tumor necrosis factor ; HCC
• 刊名：Cellular Signalling
• 出版年：2013
• 出版时间：October, 2013
• 年：2013
• 卷：25
• 期：10
• 页码：1970-1980
• 全文大小：712 K

文摘

IAPs are a group of regulatory proteins that are structurally related. Their conserved homologues have been identified in various organisms. In human, eight IAP members have been recognized based on baculoviral IAP repeat (BIR) domains. IAPs are key regulators of apoptosis, cytokinesis and signal transduction. The antiapoptotic property of IAPs depends on their professional role for caspases. IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms. IAPs impede apoptotic process via membrane receptor-dependent (extrinsic) cascade and mitochondrial dependent (intrinsic) pathway. IAP-mediated apoptosis affects the progression of liver diseases. Therapeutic options of liver diseases may depend on the understanding toward mechanisms of the IAP-mediated apoptosis.