Baculovirus expression of the N-terminus of porcine heat shock protein Gp96 improves the immunogenicity of recombinant PCV2 capsid protein
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- 作者：Xuejiao Zhua ; Jie Liua ; Juan Baia ; Panrao Liua ; Tingjie Zhanga ; Ping Jianga ; b ; jiangp@njau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xianwei Wanga ; xwwang@njau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Baculoviruses ; PCV2Cap based vaccine ; Hsps ; Gp96N
- 刊名：Journal of Virological Methods
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：230
- 期：Complete
- 页码：36-44
- 全文大小：2366 K
文摘
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Gp96 N expressed in baculoviruses enhanced humoral and Th1 cell-mediated immunity of PCV2Cap in mice.
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Gp96 N significantly enhanced humoral and Th1 bias cell-mediated immunity of PCV2Cap in piglets.
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Gp96 N enhanced protective efficacy of recombinant Cap against PCV2 challenge.