A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation
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- 作者：Shigeki Iwase1 ; 2 ; 9 ; siwase@umich.edu" class="auth_mail" title="E-mail the corresponding author ; Emily Brookes1 ; 9 ; 10 ; Saurabh Agarwal2 ; 9 ; Aimee I. Badeaux1 ; Hikaru Ito3 ; Christina N. Vallianatos2 ; Giulio Srubek Tomassy4 ; Tomas Kasza2 ; Grace Lin5 ; Andrew Thompson6 ; Lei Gu1 ; Kenneth Y. Kwan5 ; Chinfei Chen6 ; Maureen A. Sartor7 ; Brian Egan8 ; Jun Xu3 ; junxu@vetmed.wsu.edu" class="auth_mail" title="E-mail the corresponding author ; Yang Shi1 ; yshi@hms.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：9 February 2016
- 年：2016
- 卷：14
- 期：5
- 页码：1000-1009
- 全文大小：2354 K
文摘
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Behavior of Kdm5c-knockout mice recapitulates KDM5C-linked intellectual disability
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Kdm5c is required for normal dendritic branching and spine morphology in vivo
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Kdm5c acts as a repressor through reducing H3K4me3 levels at CpG promoters