Cardiotoxicity of nano-particles

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• 作者：Hasan Badie Bostan^a ; ¹ ; Ramin Rezaee^b ; ^d ; ¹ ; Mahmoud Gorji Valokala^a ; Konstantinos Tsarouhas^c ; Kirill Golokhvast^d ; Aristidis M. Tsatsakis^e ; ^{aris@med.uoc.gr" class="auth_mail" title="E-mail the corresponding author} ; Gholamreza Karimi^a ; ^{karimiG@mums.ac.ir" class="auth_mail" title="E-mail the corresponding author}
• 关键词：NPs ; nano-particles ; ROS ; reactive oxygen species ; MDA ; malondialdehyde ; SOD ; superoxide dismutase ; GST ; glutathione S-transferases ; LDH ; lactate dehydrogenase ; CK ; creatine kinase ; AST ; aspartate aminotransferase ; HBHD ; alpha-Hydroxybutyrate dehydrogenase ; NMR ; nuclear magnetic resonance ; CK-MB ; creatine kinase-MB ; NO ; nitric oxide ; BNP ; B-type natriuretic peptide ; CRP ; c-reactive protein ; CPK-MB ; creatine phosphokinase-MB ; TNF- α ; tumor necrosis factor alpha ; IL-6 ; Interleukin 6 ; FGF2 ; fibrobl
• 刊名：Life Sciences
• 出版年：2016
• 出版时间：15 November 2016
• 年：2016
• 卷：165
• 期：Complete
• 页码：91-99
• 全文大小：587 K

文摘

Nano-particles (NPs) are used in industrial and biomedical fields such as cosmetics, food additives and biosensors. Beside their favorable properties, nanoparticles are responsible for toxic effects. Local adverse effects and/or systemic toxicity are described with nanoparticle delivery to target organs of the human body. Animal studies provide evidence for the aforementioned toxicity. Cardiac function is a specific target of nanoparticles. Thus, reviewing the current bibliography on cardiotoxicity of nanoparticles and specifically of titanium, zinc, silver, carbon, silica and iron oxide nano-materials is the aim of this study.