Hydroxytyrosol targets extracellular matrix remodeling by endothelial cells and inhibits both ex vivo and in vivo angiogenesis

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• 作者：Javier A. Garcí ; a-Vilas ; Ana R. Quesada ; Miguel Á ; ngel Medina ; ^{medina@uma.es}
• 关键词：Angiogenesis ; Aortic ring assay ; Bovine aorta endothelial cells (BAEC) ; Chorioallantoic membrane (CAM) assay ; Hydroxytyrosol ; Matrix metalloproteinase (MMP) ; Tissue inhibitor of metalloproteinase (TIMP) ; Urokinase-type plasminogen activator (uPA)
• 刊名：Food Chemistry
• 出版年：2017
• 出版时间：15 April 2017
• 年：2017
• 卷：221
• 期：Complete
• 页码：1741-1746
• 全文大小：1019 K
• 卷排序：221

文摘

Hydroxytyrosol (HT) targets extracellular matrix remodeling by endothelial cells. HT decreases endothelial extracellular matrix-remodeling enzymes expression. HT increases endothelial matrix metalloproteinase inhibitors expression. HT strongly inhibits ex vivo angiogenesis in rat aortic rings. HT inhibits in vivo chorioallantoic membrane angiogenesis.