- 作者：Yonglin Gao ; Guisheng Li ; Chunmei Li ; Xiaoyin Zhu ; Min Li ; Chaolin Fu ; Bafang Li
- 关键词：Sophocarpine ; Anti-nociceptive activity ; Anti-inflammatory activity
- 刊名：Journal of Ethnopharmacology
- 出版年：2009
- 出版时间：7 September 2009
- 年：2009
- 卷：125
- 期：2
- 页码：324-329
- 全文大小：403 K
Aim of the studyThis study aimed to assess the anti-nociceptive and anti-inflammatory activity of sophocarpine in rodents.Materials and methods
The anti-nociceptive effect was evaluated in two experimental animal models and anti-inflammatory effect in three animal models, and sophocarpine was given by tail vein injection for the above study.
Results
Pretreatment with a single dose of sophocarpine (20 and 40 mg/kg) produced dose-dependent anti-nociceptive effects in thermally and chemically induced mouse pain models. Pretreatment with a single dose of sophocarpine also produced significant dose-dependent anti-inflammatory effects on carrageenan-induced rat hind paw edema (15 and 30 mg/kg), xylene-induced mouse ear edema (20 and 40 mg/kg) and acetic acid-induced mouse vascular permeation (20 and 40 mg/kg).
Conclusions
Sophocarpine possesses peripheral and central analgesic properties as well as anti-inflammatory activity on acute inflammatory processes.