Immunomodulatory activity of Alaska pollock hydrolysates obtained by glutamic acid biosensor - Artificial neural network and the identification of its active central fragment
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- 作者：Hu Hou ; houhu@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; houhuouc@163.com" class="auth_mail" title="E-mail the corresponding author ; Yan Fan ; Shikai Wang ; Leilei Si ; Bafang Li
- 关键词：Hydrolysates ; Immunomodulatory peptide ; Purification ; Amino acid sequence ; Enzymatic hydrolysis
- 刊名：Journal of Functional Foods
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：24
- 期：Complete
- 页码：37-47
- 全文大小：2132 K
文摘
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GLU-ANN was founded for preparing the target pollock hydrolysates (PFH).
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PFH enhances the humoral immunity, cellular immunity and non-specific immune function.
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Mechanism of PFH is through direct up-regulation of IL-2 IL-4 and IL-6 gene expression.
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The active central fragment was purified and identified as PTGADY.
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PFH can act as a potent immunomodulator.