Ultra-small BaGdF₅-based upconversion nanoparticles as drug carriers and multimodal imaging probes

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• 作者：Dongmei Yang ; Yunlu Dai ; Jianhua Liu ; Ying Zhou ; Yinyin Chen ; Chunxia Li ; Ping'an Ma ; Jun Lin
• 关键词：BaGdF5 ; Upconversion nanoparticle ; Drug delivery ; Multimodal imaging
• 刊名：Biomaterials
• 出版年：February, 2014
• 年：2014
• 卷：35
• 期：6
• 页码：2011-2023
• 全文大小：5384 K

文摘

A new type of drug-delivery system (DDS) was constructed, in which the anti-cancer drug doxorubicin (DOX) was conjugated to the ultra-small sized (sub-10聽nm) BaGdF₅:Yb³⁺/Tm³⁺ based upconversion nanoparticles (UCNPs). This multifunctional DDS simultaneously possesses drug delivery and optical/magnetic/X-ray computed tomography imaging capabilities. The DOX can be selectively released by cleavage of hydrazone bonds in acidic environment, which shows a pH-triggered drug release behavior. The MTT assay shows these DOX-conjugated UCNPs exhibit obvious cytotoxic effect on HeLa cells. Moreover, to improve the upconversion luminescence intensity, core-shell structured UCNPs were constructed. The in聽vitro upconversion luminescence images of these UCNPs uptaken by HeLa cells show bright emission with high contrast. In addition, these UCNPs were further explored for T₁-weighted magnetic resonance (MR) and X-ray computed tomography (CT) imaging in聽vitro. Long-term in聽vivo toxicity studies indicated that mice intravenously injected with 10聽mg/kg of UCNPs survived for 40 days without any apparent adverse effects to their health. The results indicate that this multifunctional drug-delivery system with optimized size, excellent optical/MR/CT trimodal imaging capabilities, and pH-triggered drug release property is expected to be a promising platform for simultaneous cancer therapy and bioimaging.