High-throughput Phenotyping of Lung Cancer Somatic Mutations

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• 作者：Alice H. Berger¹ ; ² ; ³ ; ¹⁰ ; Angela N. Brooks¹ ; ² ; ³ ; ¹⁰ ; ¹¹ ; Xiaoyun Wu² ; ¹⁰ ; Yashaswi Shrestha² ; Candace Chouinard² ; Federica Piccioni⁴ ; Mukta Bagul⁴ ; Atanas Kamburov² ; ³ ; ⁵ ; Marcin Imielinski¹ ; ² ; ³ ; Larson Hogstrom² ; Cong Zhu⁴ ; Xiaoping Yang⁴ ; Sasha Pantel⁴ ; Ryo Sakai⁶ ; Jacqueline Watson¹ ; ² ; Nathan Kaplan¹ ; Joshua D. Campbell¹ ; ² ; ³ ; Shantanu Singh⁷ ; David E. Root⁴ ; Rajiv Narayan² ; Ted Natoli² ; David L. Lahr² ; Itay Tirosh⁸ ; Pablo Tamayo² ; Gad Getz² ; ³ ; ⁵ ; Bang Wong² ; John Doench⁴ ; Aravind Subramanian² ; Todd R. Golub¹ ; ² ; ⁹ ; Matthew Meyerson¹ ; ² ; ³ ; ^{matthew_meyerson@dfci.harvard.edu" class="auth_mail" title="E-mail the corresponding author} ; Jesse S. Boehm² ; ^{boehm@broadinstitute.org" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Cancer Cell
• 出版年：2016
• 出版时间：8 August 2016
• 年：2016
• 卷：30
• 期：2
• 页码：214-228
• 全文大小：4019 K

文摘

<dl class="listitem" id="list_ulist0010"><dt class="label">•dt><dd>

d="p0010">Expression-based phenotyping distinguishes neutral from impactful mutations

dd><dt class="label">•dt><dd>

d="p0015">92% of missense mutations in m>KEAP1m> and m>STK11m> diminish gene function

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d="p0020">Rare variants in m>ARAFm>, m>BRAFm>, m>EGFRm>, m>ERBB2m>, m>KRASm>, and m>RIT1m> are oncogenic

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d="p0025">Erlotinib resistance induced by rare variant mutations is MEK dependent

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