Effect of Photorefractive Keratectomy on Nystagmus and Visual Functions in Myopic Patients With Infantile Nystagmus Syndrome

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• 作者：Abbas Bagheri^aAuthor Vitae ; Hamed Abbasi^a ; Mehdi Tavakoli^a ; ^{mehditavakolimd@gmail.com" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Alireza Baradaran-Rafii^a ; Abdolreza Shaibanizadeh^b ; Bahareh Kheiri^a ; Shahin Yazdani^a
• 刊名：American Journal of Ophthalmology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：162
• 期：Complete
• 页码：167-172.e2
• 全文大小：1092 K

文摘

To determine the effect of photorefractive keratectomy (PRK) on involuntary eye movements, visual acuity, and contrast sensitivity in myopic patients with infantile nystagmus syndrome.

Design

Prospective interventional case series.

Methods

This study was conducted on patients with infantile nystagmus syndrome and myopia equal to or more than −1 diopter (D), who were referred to our clinic over a 2-year period. Patients older than 18 years of age with a stable refraction for at least 1 year who were good candidates for PRK were included. Complete ophthalmologic examinations including assessment of best-corrected visual acuity (BCVA), contrast sensitivity, and videonystagmography were performed for all patients before and 3 months after surgery.

Results

Twenty-four eyes of 12 patients with mean age of 23 ± 2 years were enrolled in this study. Spherical equivalent refractive error was −2.82 ± 1.65 D and −0.26 ± 0.25 D before and after PRK, respectively (P < .001). Monocular BCVA improved from 0.36 ± 0.21 logMAR to 0.27 ± 0.25 logMAR and binocular BCVA improved from 0.33 ± 0.2 logMAR to 0.17 ± 0.16 logMAR (P < .001). Contrast sensitivity significantly improved at low (P < .001), intermediate (P < .001), and high frequencies (P = .01). The frequency, amplitude, and intensity of nystagmus were significantly decreased after PRK (P < .001). There was no correlation between the degree of myopia correction and improvement in sensory and motor indices of nystagmus (P > .1, Spearman correlation coefficient).

Conclusion

PRK in patients with infantile nystagmus syndrome and myopia improved monocular and binocular BCVA and contrast sensitivity. Furthermore, motor indices of nystagmus (frequency, amplitude, and intensity) were significantly improved after surgery in these patients.