The expression of interleukin (IL)-6, IL-8, and their receptors in fallopian tubes with ectopic tubal gestation

详细信息    查看全文

• 作者：Erin S. Balasubramaniam ; M.Sc. ; D.I.C.^a ; Susan Van Noorden ; B.Sc.^a ; Mona El-Bahrawy ; Ph.D.^a ; ^b ; ^{m.elbahrawy@imperial.ac.uk}
• 关键词：Fallopian tubes ; ectopic tubal gestation ; IL-6 ; IL-6R¦Á ; IL-8 ; CXCR1 ; CXCR2
• 刊名：Fertility and Sterility
• 出版年：2012
• 出版时间：October, 2012
• 年：2012
• 卷：98
• 期：4
• 页码：898-904
• 全文大小：721 K

文摘

| Figures/TablesFigures/Tables | ReferencesReferences

Objective

To investigate the level of expression of the cytokines interleukin (IL) -8 and IL-6 and their receptors in fallopian tubes with tubal ectopic gestation.

Design

Immunohistochemistry (IHC) was used to study the expression of IL-8, CXCR1, CXCR2, IL-6, and IL-6 receptor alpha in fallopian tubes with tubal ectopic gestation in comparison with normal fallopian tubes.

Setting

Hospital.

Patient(s)

We studied fallopian tubes from 50 patients with tubal ectopic gestation and normal fallopian tubes from 25 patients who had hysterectomy and bilateral salpingo-oopherectomy for uterine or ovarian lesions.

Intervention(s)

The expression of the chemokines/cytokines and their receptors was evaluated by IHC.

Main Outcome Measure(s)

Level of expression and tissue distribution of the different antigens.

Result(s)

IHC results showed that the expression levels of IL-6 and IL-8, as well as CXCR1, were significantly up-regulated, particularly near the implantation site in fallopian tubes with tubal gestation, while the expression levels of CXCR2 and IL-6R¦Á were not changed in comparison with normal fallopian tubes.

Conclusion(s)

The results suggest a role for IL-6, IL-8, and CXCR1 in the pathophysiology of tubal ectopic gestation.