Background: New strategies that promote clearance of excess cholesterol by reverse cholesterol transport (RCT) are needed.
Results: SOF promotion of hepatic CE uptake, metabolism and secretion as bile acids in vitro and in vivo was investigated.
Conclusion: Both in vitro and in vivo, CERM-CE is metabolized by hepatocytes to bile acids and secreted.
Significance: The SOF product CERM delivers cholesterol to the liver, supporting it as a therapeutic strategy to promote RCT.