Loss of fat-free mass over four years in adult cystic fibrosis is associated with high serum interleukin-6 levels but not tumour necrosis factor-alpha

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• 作者：Susannah J. King ; Ibolya B. Nyulasi ; Michael Bailey ; Tom Kotsimbos ; John W. Wilson
• 关键词：Body composition ; Cystic fibrosis ; Fat-free mass ; Nutritional status ; Interleukin-6
• 刊名：Clinical Nutrition
• 出版年：February, 2014
• 年：2014
• 卷：33
• 期：1
• 页码：150-155
• 全文大小：502 K

文摘

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Summary

Background & aims

Malnutrition is associated with poorer outcome in cystic fibrosis (CF). This follow-up study aimed to document nutritional status changes, including fat-free mass (FFM), in adults with CF; and to identify predictors of FFM loss.

Methods

Fifty-eight non-transplanted CF adults (mean聽卤聽SD forced expiratory volume in one second (FEV₁) 63.7聽卤聽21.4%predicted; mean聽卤聽SD age 30.3聽卤聽7.7years at baseline) were studied at baseline and 3.6聽卤聽0.4 years later. Body composition was measured using dual-energy X-ray absorptiometry. At follow-up, blood was analysed for interleukin-6 and tumour necrosis factor-伪 (TNF-伪) on three occasions over six months and averaged for each participant. Associations with annual percentage change in FFM (ann%螖FFM), including cytokines, CF genotype and annual change in FEV₁%predicted (ann螖FEV₁%), were determined.

Results

Mean FFM was 49.5聽卤聽8.8聽kg at baseline and 49.6聽卤聽8.9聽kg at follow-up (p聽=聽0.66). Ann%螖FFM ranged from聽鈭?.0 to聽+3.6%. FEV₁%predicted declined by 1.2聽卤聽2.4% per year. Forty percent of participants had elevated average interleukin-6 levels. Ann%螖FFM was negatively correlated with interleukin-6 levels (rho聽鈭?.34, p聽=聽0.008), but not TNF-伪 or ann螖FEV₁%. F508DEL homozygote or heterozygote participants had greater FFM loss than those carrying no F508DEL allele (p聽=聽0.01).

Conclusion

Higher serum interleukin-6 and presence of the F508DEL mutation, but not TNF-伪, were associated with FFM loss in adults with CF.