Patterns of response to repetitive transcranial magnetic stimulation (rTMS) in major depression: Replication study in drug-free patients

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• 作者：Eva-Lotta Brakemeier ; Gregor Wilbertz ; Silke Rodax ; Heidi Danker-Hopfe ; Bettina Zinka ; Peter Zwanzger ; Nicola Grossheinrich ; Bá ; lint Vá ; rkuti ; Rainer Rupprecht ; Malek Bajbouj ; Frank Padberg
• 关键词：Repetitive transcranial magnetic stimulation ; rTMS ; Major depressive disorder ; Response prediction ; Therapy resistance
• 刊名：Journal of Affective Disorders
• 出版年：2008
• 出版时间：May 2008
• 年：2008
• 卷：108
• 期：1-2
• 页码：59-70
• 全文大小：205 K

文摘

Repetitive transcranial magnetic stimulation (rTMS) has been found to exert modest to moderate therapeutic effects in major depression, but mechanism of action and its clinical relevance have not been clarified yet. Previous trials have reported patterns of symptomatology predicting response to rTMS. As most patients also received concomitant antidepressant medication these response patterns may rather refer to combined treatment than rTMS alone. Thus, this study aims to replicate previous findings and explore patterns of response in drug-free patients.