A new neuroprotective bakkenolide from the rhizome of Petasites tricholobus

详细信息    查看全文

• 作者：Na Zhang ; Mei Li Guo ; Ge Zhang ; Run Ping Li
• 关键词：Petasites tricholobus ; Compositae ; Bakkenolide-Va ; Neuroprotection
• 刊名：Chinese Chemical Letters
• 出版年：2008
• 出版时间：July 2008
• 年：2008
• 卷：19
• 期：7
• 页码：841-844
• 全文大小：144 K

文摘

A new bakkenolide-type compound, bakkenolide-Va(1), was isolated from the rhizome of Petasites tricholobus. The structure was characterized on the basis of various NMR (¹H, ¹³C, ¹H–¹H COSY, HMQC, HMBC and NOESY) and mass spectrometry data. The neuroprotective activity of bakkenolide-Va was investigated in primarily cultured neurons treated by hypoxia-glucose deprivation and various types of oxidative insults.