Neuroprotective bakkenolides from the roots of Valeriana jatamansi

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• 作者：Jing Xu^a ; Bo Yang^b ; Yuanqiang Guo^a ; ^{victgyq@163.com"" rel=""nofollow} ; Da-qing Jin^c ; Ping Guo^a ; Cuizhou Liu^a ; Wenbin Hou^d ; Tiejun Zhang^d ; Liping Gui^a ; Zhanping Sun^a
• 关键词：Valeriana jatamansi ; Bakkenolide ; Neuroprotective effect ; MPP⁺ ; Sesquiterpene
• 刊名：Fitoterapia
• 出版年：2011
• 出版时间：September 2011
• 年：2011
• 卷：82
• 期：6
• 页码：849-853
• 全文大小：552 K

文摘

Two new bakkenolides, valerilactones A (1), and B (2), and two known analogues, bakkenolide-H (3) and bakkenolide-B (4), were isolated from the roots of Valeriana jatamansi. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR) and by comparison of their NMR data with those of related compounds. Compounds 1, 2, and 3 exhibited potent neuroprotective effects against MPP⁺-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.