Ketamine treatment involves medial prefrontal cortex serotonin to induce a rapid antidepressant-like activity in BALB/cJ mice
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- 作者：T.H. Phama ; 1 ; I. Mendez-Davida ; 1 ; C. Defaixa ; B.P. Guiardb ; L. Tritschlera ; D.J. Davida ; A.M. Gardiera ; alain.gardier@u-psud.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ketamine ; Serotonin ; Rapid antidepressant-like activity ; Medial prefrontal cortex ; Dorsal raphe nucleus ; Antidepressant drug ; Highly anxious BALB/cJ mice ; Microdialysis
- 刊名：Neuropharmacology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：112
- 期：part_PA
- 页码：198-209
- 全文大小：816 K
文摘
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Unlike fluoxetine, ketamine induced persistent antidepressant-like effect in mice.
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Ketamine increase cortical, but not [5-HT]ext in the dorsal raphe nucleus.
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Increases in cortical 5-HT is required for ketamine’s antidepressant-like activity.
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Activation of DRN AMPA receptors and of the prefrontal cortex/brainstem DRN neural circuit are required for ketamine’s antidepressant-like activity in BALB/c mice.