Immunization with Leishmania donovani protein disulfide isomerase DNA construct induces Th1 and Th17 dependent immune response and protection against experimental visceral leishmaniasis in Balb/c mice

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• 作者：Ajay Amit^a ; Vijayamahantesh^a ; ^c ; Manas R. Dikhit^a ; ^b ; Ashish Kumar Singh^a ; ^d ; Vikash Kumar^a ; Shashi S. Suman^f ; Ashu Singh^c ; Akhilesh Kumar^a ; Ajit Kumar Thakur^h ; Vidyanand Ravi Das^e ; Pradeep Das^g ; Sanjiva Bimal^a ; ^{drsbimal24@yahoo.com} ; ^{drsanjiba.rmri@gmail.com}
• 关键词：Protein disulfide isomerase (PDI) ; DNA vaccine ; Interleukin (IL)-17A ; Nitric oxide ; Mitogen-activated protein kinase (MAPK) ; Visceral leishmaniasis ; Interferon gamma
• 刊名：Molecular Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：82
• 期：Complete
• 页码：104-113
• 全文大小：2126 K
• 卷排序：82

文摘

Recombinant Leishmania donovani PDI is recognised in sera of VL patient. Immunization of BALB/c mice with LdPDI as DNA construct leads to enhance the T-cell proliferation. LdPDI-construct has the ability to trigger both Th17 and Th1 cells response in immunized mice. LdPDI-construct vaccination may ensure persistent IL-2 production and show high durability till a longer period of time.