Effect of depolymerized sodium alginate on Salmonella Typhimurium infection in human enterocyte-like HT-29-Luc cells and BALB/c mice
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- 作者：Takashi Kuda ; kuda@kaiyodai.ac.jp ; Shino Hirano ; Yasushi Yokota ; Mika Eda ; Hajime Takahashi ; Bon Kimura
- 关键词：Alginate ; Depolymerized alginate ; Salmonella Typhimurium ; HT-29-Luc cells ; BALB/c mice
- 刊名：Journal of Functional Foods
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：28
- 期：Complete
- 页码：122-126
- 全文大小：503 K
- 卷排序：28
文摘
Alginate (HM-NA) is a highly viscous polysaccharide in brown algae. Depolymerized alginate (LM-NA) is less viscous with low molecular weight (∼50 kDa). Both alginates inhibited S. Typhimurium adhesion and invasion in HT-29-Luc cells. Both alginates (2%) in the diet suppressed S. Typhimurium infection in mouse liver. LM-NA (2.5%) drinking water inhibited S. Typhimurium infection in liver and spleen.