Sex-comparative study of mouse cerebellum physiology under adult-onset hypothyroidism: The significance of GC-MS metabolomic data normalization in meta-analysis

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• 作者：Christoniki Maga-Nteve^a ; ^c ; ¹ ; Catherine G. Vasilopoulou^a ; ^b ; ¹ ; Caterina Constantinou^a ; ² ; Marigoula Margarity^b ; Maria I. Klapa^a ; ^d ; ^{mklapa@iceht.forth.gr}
• 关键词：GC&ndash ; MS metabolomic data validation and normalization ; Mammalian brain metabolism ; Adult-onset hypothyroidism (AOH) ; Balb/cJ mouse cerebellum ; Metabolic network analysis ; Systems biology
• 刊名：Journal of Chromatography B
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：1041-1042
• 期：Complete
• 页码：158-166
• 全文大小：2369 K
• 卷排序：1041

文摘

Sex-comparative metabolomics of mouse cerebellum under adult-onset-hypothyroidism. First sex-comparative brain metabolomic analysis under adult-onset-hypothyroidism. Systematic normalization of two GC–MS metabolomic datasets ensures meta-analysis. Milder adult-onset-hypothyroidism effect on female mouse cerebellum-cb metabolism. Female mouse cb metabolism appears conditioned at lower free metabolite quantities.