- 作者：Walter Gubelin Harcha ; Julia Barboza Mart铆nez ; Tsen-Fang Tsai ; Kensei Katsuoka ; Makoto Kawashima ; Ryoji Tsuboi ; Allison Barnes ; Geraldine Ferron-Brady ; Dushen Chetty
- 关键词：5-alpha reductase ; 5-alpha reductase inhibitors ; androgenetic alopecia ; dutasteride ; finasteride ; male pattern baldness ; male pattern hair loss ; treatment
- 刊名：Journal of the American Academy of Dermatology
- 出版年：March, 2014
- 年：2014
- 卷：70
- 期：3
- 页码：489-498.e3
- 全文大小：1162 K
Background
Dihydrotestosterone is the main androgen causative of androgenetic alopecia, a psychologically and physically harmful condition warranting medical treatment.Objective
We sought to compare the efficacy and safety of dutasteride (type 1 and 2 5-alpha reductase inhibitor) with finasteride (type 2 5-alpha reductase inhibitor) and placebo in men with androgenetic alopecia.
Methods
Men aged 20 to 50 years with androgenetic alopecia were randomized to receive dutasteride (0.02, 0.1, or 0.5 mg/d), finasteride (1 mg/d), or placebo for 24 weeks. The primary end point was hair count (2.54-cm diameter) at week 24. Other assessments included hair count (1.13-cm diameter) and width, photographic assessments (investigators and panel), change in stage, and health outcomes.
Results
In total, 917 men were randomized. Hair count and width increased dose dependently with dutasteride. Dutasteride 0.5 mg significantly increased hair count and width in a 2.54-cm diameter and improved hair growth (frontal view; panel photographic assessment) at week 24 compared with finasteride (P聽= .003, P聽= .004, and P聽= .002, respectively) and placebo (all P < .001). The number and severity of adverse events were similar among treatment groups.
Limitations
The study was limited to 24 weeks.
Conclusions
Dutasteride increased hair growth and restoration in men with androgenetic alopecia and was relatively well tolerated.