Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

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• 作者：Weifei Zhu¹ ; ⁷ ; Jill C. Gregory¹ ; ⁷ ; Elin Org² ; Jennifer A. Buffa¹ ; Nilaksh Gupta¹ ; Zeneng Wang¹ ; Lin Li¹ ; Xiaoming Fu¹ ; Yuping Wu⁵ ; Margarete Mehrabian² ; R. Balfour Sartor³ ; Thomas M. McIntyre¹ ; Roy L. Silverstein⁴ ; W.H. Wilson Tang¹ ; ⁶ ; Joseph A. DiDonato¹ ; J. Mark Brown¹ ; Aldons J. Lusis² ; Stanley L. Hazen¹ ; ⁶ ; ^{hazens@ccf.org" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Cell
• 出版年：2016
• 出版时间：24 March 2016
• 年：2016
• 卷：165
• 期：1
• 页码：111-124
• 全文大小：4080 K

文摘

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d="p0010">Elevated TMAO levels predict incident risk for thrombotic events in human subjects

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d="p0015">TMAO enhances sub-maximal stimulus-dependent platelet activation

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d="p0020">Dietary choline, gut microbes, and TMAO are linked to thrombotic potential in vivo

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d="p0025">Microbial transplantation shows that thrombosis potential is a transmissible trait

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