Triterpenoids from Momordica balsamina: Reversal of ABCB1-mediated multidrug resistance
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- 作者：Cá ; tia Ramalhetea ; &dagger ; ; catiar@uatlantica.pt" class="auth_mail" title="E-mail the corresponding author ; Silva Mulhovob ; Joseph Molnarc ; Maria-José ; U. Ferreiraa ; mjuferreira@ff.ulisboa.pt" class="auth_mail" title="E-mail the corresponding author
- 关键词：FDINJVUVNVFMKX-NGPVLLJVSA-N ; AVFNYXHRDYAHNF-HEVJPHJFSA-N ; LJWAEAIXBCCHLR-ITWKNSBQSA-N ; XIQPIAMRFKEZPL-IQOYCCEYSA-N ; NBZHVWXCQLFQNW-ATYSFEEYSA-N ; NBZHVWXCQLFQNW-ATYSFEEYSA-N ; HTVYFULXCNCIQP-RWAKPREXSA-N ; WKIUWXJRQZRPNJ-HCBDOCHMSA-N ; CUZSOMMGOJSRQM-QGHMFDTNSA-N ; LAMQCISFLOCMTF-KHSSJYCYSA-N ; WFULNIMUTJQIKF-HCLZVIJHSA-N ; OSNWCRUHKQXEMA-KOBRMIIQSA-N ; HSJCULHTPJTWAJ-SOKCMQJFSA-N ; BZKMSMPQWDQSDS-UHFFFAOYSA-N ; GCSGWQIIVZDSSY-DUZPDYNRSA-N ; WLDPKTWPLRBAMQ-IXDFPWEYSA-N ; LONNOTBMXUGTQD-PRQXAQKWSA-N ; NNEMUGG
- 刊名：Bioorganic & Medicinal Chemistry
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：24
- 期：21
- 页码：5061-5067
- 全文大小：460 K
文摘
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Thirty natural and semi-synthetic triterpenoids were evaluated as ABCB1 modulators.
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Most of the natural compounds displayed strong MDR reversing activity.
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Some of the most active modulators synergistically interact with doxorubicin.
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Balsaminols B and C are among the most promising modulators.
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Substitution patterns in the molecule play important role in ABCB1 reversal activity.