Localised interventions in cellular processes

详细信息    查看全文

• 作者：Nick Peel^a ; ^{Nick.Peel@cancer.org.uk} ; Banafsh&eacute ; Larijani^b ; Peter J. Parker^a ; ^c ; ^{Peter.Parker@cancer.org.uk}
• 关键词：Spatial signaling ; Phospholipid ; Rapalogue ; Inhibitor ; Membrane ; Dimerization
• 刊名：Biochimica et Biophysica Acta - Proteins and Proteomics
• 出版年：2013
• 出版时间：July, 2013
• 年：2013
• 卷：1834
• 期：7
• 页码：1364-1370
• 全文大小：2168 K

文摘

The once linear view of cell regulatory processes is now changing as we begin to overlay spatial and temporal characteristics onto signalling pathways and dynamic membranous events. To better understand the properties of these spatially restricted processes we must refine our targeting of these events with acute localised manipulations. We review here the diverse application of a dimerisation system, which exploits immunosuppressor/immunophilin biology to provide a route to drug-inducible subdomain interventions. This article is part of a Special Issue entitled: Inhibitors of Protein Kinases (2012).