Validation of a GC-MS method for the estimation of dithiocarbamate fungicide residues and safety evaluation of mancozeb in fruits and vegetables

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• 作者：Sumaiyya Mujawar ; Sagar C. Utture ; Eddie Fonseca ; Jessie Matarrita ; Kaushik Banerjee
• 关键词：Dithiocarbamate fungicides ; Mancozeb ; GC&ndash ; MS ; Selected ion monitoring ; Method validation ; Pre-harvest interval
• 刊名：Food Chemistry
• 出版年：1 May, 2014
• 年：2014
• 卷：150
• 期：Complete
• 页码：175-181
• 全文大小：464 K

文摘

A sensitive and rugged residue analysis method was validated for the estimation of dithiocarbamate fungicides in a variety of fruit and vegetable matrices. The sample preparation method involved reaction of dithiocarbamates with Tin(II) chloride in aqueous HCl. The CS₂ produced was absorbed into an isooctane layer and estimated by GC-MS selected ion monitoring. Limit of quantification (LOQ) was 猢?0 渭g kg^鈭? for grape, green chilli, tomato, potato, brinjal, pineapple and chayote and the recoveries were within 75-104% (RSD < 15% at LOQ). The method could be satisfactorily applied for analysis of real world samples. Dissipation of mancozeb, the most-used dithiocarbamate fungicide, in field followed first + first order kinetics with pre-harvest intervals of 2 and 4 days in brinjal, 7 and 10 days in grapes and 0 day in chilli at single and double dose of agricultural applications. Cooking practices were effective for removal of mancozeb residues from vegetables.