Solubility determination and thermodynamic modelling of allisartan isoproxil in different binary solvent mixtures from T = (278.15 to 313.15) K and mixing properties of solutions
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- 作者：Yaoyao Yang ; Peng Yang ; Shichao Du ; Kangli Li ; Kaifei Zhao ; Shijie Xu ; Baohong Hou ; Junbo Gong ; junbo_gong@tju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Allisartan isoproxil ; Solubility ; Solubility parameter ; Thermodynamic models
- 刊名：Journal of Chemical Thermodynamics
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：103
- 期：Complete
- 页码：432-445
- 全文大小：2520 K
文摘
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The solubility of allisartan isoproxil in binary solvent mixtures were determined.
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Apelblat, CNIBS/R-K and Jouyban-Acree models were used to correlate the solubility.
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Solubility parameter theory was used to explain the co-solvency phenomenon.
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Regular mixing rules were used to calculate solubility parameter of binary solvents.
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The mixing thermodynamics were calculated and discussed based on NRTL model.