Overexpression Bax interacting factor-1 protects cortical neurons against cerebral ischemia-reperfusion injury through regulation of ERK1/2 pathway
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- 作者：Qiang Yuna ; b ; 1 ; Mingfang Jiangc ; 1 ; Jun Wangd ; Xiangyu Caod ; Xinfeng Liud ; Sheng Lid ; Baomin Lid ; bmlixian@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bif-1 ; Bax interacting factor-1 ; 3-MA ; 3-Methyladenine ; OGD/R ; oxygen and glucose deprivation followed by reperfusion ; MTT ; 3-(4 ; 5-dimethylthi-azol-2-yl)-2 ; 5-diphenyl-tetrazolium bromide ; ECL ; enhanced chemiluminescence
- 刊名：Journal of the Neurological Sciences
- 出版年：2015
- 出版时间：15 October 2015
- 年：2015
- 卷：357
- 期：1-2
- 页码：183-191
- 全文大小：1703 K
文摘
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Bif-1 improves OGD/R-induced cortical neurons survival and autophagy.
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Bif-1 inhibits OGD/R-induced cell apoptosis and the activity of caspase-3.
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Cell autophagy inhibitor 3-MA suppresses OGD/R-induced cortical neurons survival.
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Inhibition Bif-1 promotes OGD/R-induced cell autophagy in cortical neurons.
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ERK1/2 pathway is involved in the effects of Bif-1 on OGD/R-induced cell survival.