- 作者：Andrei Barasch ; Monika M. Safford ; Ingrida Dapkute-Marcus ; Daniel H. Fine
- 刊名：Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
- 出版年：2004
- 出版时间：February 2004
- 年：2004
- 卷：97
- 期：2
- 页码：204-207
- 全文大小：58 K
Purpose
We evaluated the effect of chlorhexidine (CHX) 0.12 % rinses on the clinical and microbiologic manifestations of oral candidiasis in HIV-infected children.Study design
This was a cross-sectional, clinical intervention study of 38 HIV-positive children. Inclusion in the study was based on oral examination and positive oral culture for Candida. At baseline, subjects with no clinical lesions but who were culture-positive for Candida (N = 9) were placed on preventive therapy of CHX q.d. for 90 days. Subjects with clinical oral candidiasis (N = 9) were placed on therapeutic CHX b.i.d. All 38 subjects received oral exams at monthly intervals. At 90 days oral mucosal samples were again taken for Candida. Colony-forming units (CFU) were determined before and after CHX treatment.
Results
Of 18 culture-positive subjects, 12 were included in the CFU analyses. After 3 months of CHX oral rinse therapy, Candida was undetectable in 3 children; another 8 showed an average 2-fold reduction in CFU. In 1 child the number of CFU increased modestly. Overall, the average pre- and posttreatment mean CFU was 6.18 ± 2.19 and 2.73 ± 3.15, respectively (P = .009). Five patients with clinical oral candidiasis at baseline, including all 3 who had pseudomembranous candidiasis, were free of signs of disease at the end of the study.
Conclusions
This study suggests that the topical disinfectant CHX may be a promising agent for treating and preventing oral candidiasis in HIV-infected children.