Oral toxicity management in head and neck cancer patients treated with chemotherapy and radiation: Xerostomia and trismus (Part 2). Literature review and consensus statement

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• 作者：Michela Buglione^a ; ^{michela.buglione@unibs.it" class="auth_mail" title="E-mail the corresponding author} ; Roberta Cavagnini^a ; ^{rcnero@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Federico Di Rosario^b ; ^{fedric81@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Marta Maddalo^a ; ^{marta.maddalo@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Lucia Vassalli^c ; ^{lucia.vassalli@libero.it" class="auth_mail" title="E-mail the corresponding author} ; Salvatore Grisanti^c ; ^{salvatore.grisanti@tin.it" class="auth_mail" title="E-mail the corresponding author} ; Stefano Salgarello^b ; ^{stefano.salgarello@unibs.it" class="auth_mail" title="E-mail the corresponding author} ; Ester Orlandi^d ; ^{Ester.Orlandi@istitutotumori.mi.it" class="auth_mail" title="E-mail the corresponding author} ; Paolo Bossi^e ; ^{paolo.bossi@istitutotumori.mi.it" class="auth_mail" title="E-mail the corresponding author} ; Alessandra Majorana^b ; ^{alessandra.majorana@unibs.it" class="auth_mail" title="E-mail the corresponding author} ; Giorgio Gastaldi^b ; ^{giorgio.gastaldi@unibs.it" class="auth_mail" title="E-mail the corresponding author} ; Alfredo Berruti^c ; ^{alfredo.berruti@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Fabio Trippa^f ; ^{f.trippa@aospterni.it" class="auth_mail" title="E-mail the corresponding author} ; Pietro Nicolai^g ; ^{piero.nicolai@unibs.it" class="auth_mail" title="E-mail the corresponding author} ; Andrei Barasch^h ; ^{barasaff@cs.com" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Elvio G. Russiⁱ ; ^{elviorussi@gmail.com" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Judith Raber-Durlacher^j ; ^k ; ^{j.e.raberdurlacher@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Barbara Murphy^l ; ^{barbara.murphy@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Stefano M. Magrini^a ; ^{stefano.magrini@unibs.it" class="auth_mail" title="E-mail the corresponding author}Author Vitae
• 关键词：Head and neck cancer ; Xerostomia ; Trismus ; Radiotherapy ; Chemotherapy ; Radio-induced xerostomia ; Radio-induced trismus
• 刊名：Critical Reviews in Oncology and Hematology
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：102
• 期：Complete
• 页码：47-54
• 全文大小：697 K

文摘

Radiotherapy alone or in combination with chemotherapy and/or surgery is a well-known radical treatment for head and neck cancer patients. Nevertheless acute side effects (such as moist desquamation, skin erythema, loss of taste, mucositis etc.) and in particular late toxicities (osteoradionecrosis, xerostomia, trismus, radiation caries etc.) are often debilitating and underestimated.

A multidisciplinary group of head and neck cancer specialists from Italy met in Milan with the aim of reaching a consensus on a clinical definition and management of these toxicities.

The Delphi Appropriateness method was used for this consensus and external experts evaluated the conclusions. The paper contains 20 clusters of statements about the clinical definition and management of stomatological issues that reached consensus, and offers a review of the literature about these topics.

The review was split into two parts: the first part dealt with dental pathologies and osteo-radionecrosis (10 clusters of statements), whereas this second part deals with trismus and xerostomia (10 clusters of statements).