Preliminary evaluation of pharmacological properties of some xanthone derivatives

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• 作者：Henryk Marona ; Natalia Szkaradek ; Anna Rapacz ; Barbara Filipek ; Mał ; gorzata Dybał ; a ; Agata Siwek ; Marek Cegł ; a ; Edward Szneler
• 关键词：Xanthones ; Antiarrhythmic ; hypotensive and anticonvulsive activities ; Radioligand-binding assay
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2009
• 出版时间：1 February 2009
• 年：2009
• 卷：17
• 期：3
• 页码：1345-1352
• 全文大小：1103 K

文摘

A series of xanthone derivatives were synthesized and examined for electrocardiographic, antiarrhythmic, hypotensive and anticonvulsant activities as well as for α₁- and β₁-adrenergic binding affinities. Among the investigated compounds, some of them exhibited significant antiarrhythmic and/or hypotensive activity. The data obtained via receptor binding assay are in agreement with pharmacological results and could explain antiarrhythmic and/or hypotensive activity of the newly synthesized structures.