Preventing Allograft Rejection by Targeting Immune Metabolism
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- 作者：Chen-Fang Lee1 ; 2 ; Ying-Chun Lo1 ; Chih-Hsien Cheng1 ; 2 ; Georg J. Furtmü ; ller3 ; Byoungchol Oh3 ; Vinicius Andrade-Oliveira1 ; Ajit G. Thomas4 ; Caitlyn E. Bowman5 ; Barbara S. Slusher4 ; Michael J. Wolfgang5 ; Gerald Brandacher3 ; Jonathan D. Powell1 ; poweljo@jhmi.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：27 October 2015
- 年：2015
- 卷：13
- 期：4
- 页码：760-770
- 全文大小：2788 K
文摘
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Metabolic reprogramming is crucial for effector T cell differentiation and function
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Blocking glycolysis and glutamine metabolism can prevent allograft rejection
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Targeting effector cell metabolism preserves mechanisms of immunoregulation
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Targeting metabolism represents a paradigm-shifting approach to transplantation