N-phenyl-1H-pyrazole-4-carboxamide derivatives were synthesized.
The pyrazole-4-carboxamides were evaluated for the biofilm formation reduction of Staphylococcus aureus strains.
The synthesized compounds inhibit the biofilm formation of all the tested bacterial strains.
Compound 14d also shows a good protective effect in vivo by improving the survival of wax moth larva infected with S. aureus.